Compound profile · Recovery research

Ipamorelin

A selective ghrelin-receptor agonist studied for clean GH pulses without cortisol spill.

Tissue research Janoshik verified
StatusResearch use only
BPC-157 - 10 mg
BPC-157 - 10 mg
Dhs. 349.00
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01

Selective by design.

Ipamorelin is a pentapeptide ghrelin-receptor (GHSR-1a) agonist. Its appeal in research is selectivity: it stimulates growth-hormone release with little to no rise in cortisol or prolactin, unlike earlier secretagogues.

01
GHS-R agonism
Activates the ghrelin receptor to amplify GH pulses.
02
Clean profile
Minimal cortisol / prolactin elevation in studies.
03
GHRH complement
Paired with CJC-1295 for dual-pathway GH release.
Primary structure
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
C38 H49 N9 O5 · 711.85 g/mol
Calculate your reconstitution dosage →
03

At a glance

5
Amino acids
~2h
Min half-life (rat)
GHSR-1a
CAS
04

The amplifier in the pair.

Where CJC-1295 supplies the GHRH 'go' signal, Ipamorelin amplifies the resulting pulse through the ghrelin-receptor pathway. The two activate different receptors that converge on GH release.

Ipamorelin's selectivity is its defining research trait - earlier GHS compounds raised cortisol and prolactin, which Ipamorelin largely avoids in study settings.

05

Not all claims are equal.

Tier 01
Strongest support
  • Selective GH release with minimal cortisol/prolactin
  • Ghrelin-receptor agonism well characterised
  • Documented synergy with GHRH analogs
Tier 02
Moderate support
  • IGF-1 elevation downstream
  • Body-composition signals in limited studies
  • Appetite/GI effects via ghrelin pathway
Tier 03
Emerging / unverified
  • Long-term human safety
  • Anti-ageing claims
  • Optimal research protocols
06

How it works

01
Ghrelin receptor

Selective GHSR-1a agonist driving GH secretion.

Characterized
02
Low spill-over

Minimal cortisol/prolactin elevation vs older GHS.

Documented
03
Pulse synergy

Combines with GHRH analogs for ~2–3× GH output.

Research
04
IGF-1 axis

Feeds downstream IGF-1 signalling.

Downstream
07

How it moves through the system

AdministrationPeakHalf-lifeCleared
Peak 50% Cleared
30 - 60 min
Onset to peak
~2 h
Half-life
hours
Largely cleared
Curve shape is illustrative; figures reflect pharmacokinetics reported in research — rapid local metabolism, figures from animal IV/IM data.
08

Used in the lab, not the clinic

Reference figures describe how this compound is handled and dosed in research. These are not instructions for human use.

Format & handling
Research formatLyophilised
ReconstitutionBacteriostatic water
Cold-chainRecommended
In the literature
Doses in literatureµg/kg (animal)
Storage−20 °C lyophilised
Stability (reconstituted)~weeks, refrigerated
09

Reconstitution calculator

How much diluent to mix into the vial, and the concentration that results. The suggested volume reaches a clean working stock; the calculator does the arithmetic from figures you enter. These describe solution preparation for research handling — not instructions for use in humans or animals.

Suggested reconstitution Reconstitute the 10 mg vial with 2 mL bacteriostatic water → 5.0 mg/mL (5000 mcg/mL)
Concentration—
Volume / aliquot—
U-100 units—
Aliquots / vial—
Concentration = compound ÷ diluent. Volume per aliquot = target ÷ concentration. U-100 units are a volume readout (1 mL = 100 units). Figures are for research solution preparation only — not instructions for use in humans or animals.
010

Signs of a quality compound

Lyophilised cake or powder
A fine, fluffy white cake — not oily, clumped or discoloured.
Clear reconstitution
Dissolves to a clear, colourless solution with no visible particles or cloudiness.
Batch-specific COA
Independent HPLC purity and mass-spec identity for the exact lot — not a recycled generic PDF.
Intact seal & vacuum
Sealed flip-top vial under vacuum; correct fill; legible batch and storage marking.
Walk away if…
No COA, oily residue, off-colour, partial vacuum, or purity claims with no independent test behind them.
Suspiciously cheap
Pricing far below the market for a well-tested compound usually means skipped testing or underfilled vials.
Regulatory & status
Clean, selective, investigational.

Ipamorelin is not approved for human use and is supplied as a research compound. Prohibited in competitive sport.

Status
Investigational research compound
Approval
Not FDA-approved
Anti-doping
Prohibited in sport
Pairing
Studied with CJC-1295
Research handling
Important notices
  • For research purposes only
  • Not for human consumption
  • Not FDA approved
  • Consult a qualified professional
Important

For research use only. Not for human consumption. Apex Academy is an educational reference describing findings reported in published and preclinical literature. Nothing here is medical advice, a protocol, or a recommendation to administer any compound to humans or animals. Many compounds described are investigational and are not approved by the FDA or other regulators for the prevention, treatment, or cure of any condition. Their long-term safety and pharmacokinetics remain incompletely characterized. Dose ranges, where shown, describe quantities used in cited research models - not instructions for use. Consult a qualified, licensed professional before making any health decision.