Compound profile · Recovery research

SEMAX

An ACTH(4-10) fragment analog studied for neuroprotection and focus.

Tissue research METS verified
StatusResearch use only
BPC-157
BPC-157
Dhs. 300.00
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01

A fragment for focus.

Semax is a synthetic analog of a fragment of ACTH, developed in Russia and studied for neuroprotective and cognitive-enhancing effects without the hormonal action of full ACTH.

01
BDNF up-regulation
Among the more consistent findings - raised BDNF/NGF expression.
02
Neuroprotection
Studied in stroke and ischaemia models in Russian research.
03
Dopaminergic tone
Linked to modulation of attention and motivation circuits.
Primary structure
Met-Glu-His-Phe-Pro-Gly-Pro
C37 H51 N9 O10 S · 813.9 g/mol
Calculate your reconstitution dosage →
03

At a glance

7
Amino acids
BDNF/NGF
Pathway
Intranasal
Research route
04

A neurotrophic nudge.

Semax's most consistent research signal is up-regulation of BDNF and NGF - the neurotrophins involved in neuronal growth and protection.

Beyond that it has been studied for neuroprotection in ischaemia models and for effects on attention and monoamine tone. As with Selank, its clinical record sits mainly in Russian medicine; Western validation in healthy populations is thin.

05

Not all claims are equal.

Tier 01
Strongest support
  • BDNF / NGF up-regulation (replicated in models)
  • Neuroprotective signals in ischaemia models
  • Russian clinical use in stroke recovery
Tier 02
Moderate support
  • Attention and cognitive-performance signals
  • Dopaminergic / monoamine modulation
  • Antioxidant activity in brain tissue
Tier 03
Emerging / unverified
  • Western-validated cognitive enhancement
  • Long-term safety
  • Healthy-population nootropic claims
06

How it works

01
Neurotrophins

Raises BDNF and NGF expression in brain models.

Replicated
02
Neuroprotection

Protective in ischaemia / oxidative-stress models.

Preclinical
03
Monoamines

Modulates dopaminergic and serotonergic tone.

Mechanistic
04
BBB peptide

Crosses the blood-brain barrier as a small peptide.

Research
07

How it moves through the system

AdministrationPeakHalf-lifeCleared
Peak 50% Cleared
minutes
Onset to peak
minutes
Half-life
<1 h
Largely cleared
Curve shape is illustrative; figures reflect pharmacokinetics reported in research - rapid local metabolism, figures from animal IV/IM data.
08

Reconstitution calculator

How much diluent to mix into the vial, and the concentration that results. The suggested volume reaches a clean working stock; the calculator does the arithmetic from figures you enter. These describe solution preparation for research handling — not instructions for use in humans or animals.

Suggested reconstitution Reconstitute the 10 mg vial with 2 mL bacteriostatic water → 5.0 mg/mL (5000 mcg/mL)
Concentration—
Volume / aliquot—
U-100 units—
Aliquots / vial—
Concentration = compound ÷ diluent. Volume per aliquot = target ÷ concentration. U-100 units are a volume readout (1 mL = 100 units). Figures are for research solution preparation only — not instructions for use in humans or animals.
09

Signs of a quality compound

Lyophilised cake or powder
A fine, fluffy white cake — not oily, clumped or discoloured.
Clear reconstitution
Dissolves to a clear, colourless solution with no visible particles or cloudiness.
Batch-specific COA
Independent HPLC purity and mass-spec identity for the exact lot — not a recycled generic PDF.
Intact seal & vacuum
Sealed flip-top vial under vacuum; correct fill; legible batch and storage marking.
Walk away if…
No COA, oily residue, off-colour, partial vacuum, or purity claims with no independent test behind them.
Suspiciously cheap
Pricing far below the market for a well-tested compound usually means skipped testing or underfilled vials.
Regulatory & status
Clinical in Russia, research elsewhere.

Semax is used clinically in Russia but is investigational and unapproved in most Western markets, where it is supplied as a research compound.

Status
Research compound
History
Russian clinical use
Approval
Not FDA-approved
Route
Intranasal in research
Research handling
Important notices
  • For research purposes only
  • Not for human consumption
  • Not FDA approved
  • Consult a qualified professional
Important

For research use only. Not for human consumption. Apex Academy is an educational reference describing findings reported in published and preclinical literature. Nothing here is medical advice, a protocol, or a recommendation to administer any compound to humans or animals. Many compounds described are investigational and are not approved by the FDA or other regulators for the prevention, treatment, or cure of any condition. Their long-term safety and pharmacokinetics remain incompletely characterized. Dose ranges, where shown, describe quantities used in cited research models - not instructions for use. Consult a qualified, licensed professional before making any health decision.