Compound profile · Recovery research

Sermorelin

An older growth-hormone-releasing peptide with a long clinical history.

Tissue research METS verified
StatusResearch use only
BPC-157
BPC-157
Dhs. 300.00
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01

The original GHRH fragment.

Sermorelin is the active 1-29 fragment of GHRH and one of the longest-used GH peptides. It was an approved drug for decades before being discontinued commercially, and is now widely prepared by compounding pharmacies.

01
Long history
Used clinically since the 1990s, including in paediatric GH testing.
02
Short-acting
Produces a natural GH pulse and clears quickly.
03
Compounded today
No longer sold as a branded drug; prepared by compounders and sold as research.
Primary structure
GRF (1-29)
GHRH (1-29) · 29 amino acids
Calculate your reconstitution dosage →
03

At a glance

29
Amino acids
1990s
In clinical use
GHRH-R
Target
04

Where the research focuses.

01
GH stimulation

Raises the body's own GH through a short, natural pulse.

02
Paediatric GH testing

Historically used to assess growth-hormone deficiency.

03
Recovery & sleep

GH pulses tie into deep sleep and tissue recovery.

04
Anti-ageing GH support

Popular in compounded protocols for age-related GH decline.

05

A familiar, gentle pulse.

Sermorelin stimulates the body's own GH in a short, natural pulse rather than flooding the system - the reason it has a long track record and a gentle reputation.

Its branded form was discontinued for commercial reasons, not safety, and it remains widely compounded.

06

Strength of the evidence.

Tier 01
Strongest support
  • Decades of clinical use
  • GH-stimulation mechanism established
Tier 02
Moderate support
  • Body-composition and sleep signals
  • Compounded clinical experience
Tier 03
Emerging / unverified
  • Anti-ageing outcome claims
  • Long-term healthy-adult data
07

How it works

01
GHRH receptor

Agonist driving a physiological GH pulse.

Established
02
Short action

Clears quickly, preserving natural rhythm.

Characterised
03
IGF-1 axis

Modest downstream IGF-1 rise.

Documented
04
Tolerability

Long, generally favourable safety record.

Clinical
08

How it moves through the system

AdministrationPeakHalf-lifeCleared
Peak 50% Cleared
~10–30 min
Onset to peak
~10–20 min
Half-life
<1 h
Largely cleared
Curve shape is illustrative; figures reflect pharmacokinetics reported in research - rapid local metabolism, figures from animal IV/IM data.
09

Reconstitution calculator

How much diluent to mix into the vial, and the concentration that results. The suggested volume reaches a clean working stock; the calculator does the arithmetic from figures you enter. These describe solution preparation for research handling — not instructions for use in humans or animals.

Suggested reconstitution Reconstitute the 10 mg vial with 2 mL bacteriostatic water → 5.0 mg/mL (5000 mcg/mL)
Concentration—
Volume / aliquot—
U-100 units—
Aliquots / vial—
Concentration = compound ÷ diluent. Volume per aliquot = target ÷ concentration. U-100 units are a volume readout (1 mL = 100 units). Figures are for research solution preparation only — not instructions for use in humans or animals.
010

Signs of a quality compound

Lyophilised cake or powder
A fine, fluffy white cake — not oily, clumped or discoloured.
Clear reconstitution
Dissolves to a clear, colourless solution with no visible particles or cloudiness.
Batch-specific COA
Independent HPLC purity and mass-spec identity for the exact lot — not a recycled generic PDF.
Intact seal & vacuum
Sealed flip-top vial under vacuum; correct fill; legible batch and storage marking.
Walk away if…
No COA, oily residue, off-colour, partial vacuum, or purity claims with no independent test behind them.
Suspiciously cheap
Pricing far below the market for a well-tested compound usually means skipped testing or underfilled vials.
Regulatory & status
Discontinued, not disproven.

Sermorelin's branded form (Geref) was discontinued for commercial reasons. It is now compounded and sold as a research material, and is prohibited in competitive sport. Its long history is a point in its favour.

History
Formerly FDA-approved (Geref)
Now
Compounded / research
Evidence
Long clinical track record
Anti-doping
Prohibited in sport (WADA)
Research handling
Important notices
  • For research purposes only
  • Not for human consumption
  • Not FDA approved
  • Consult a qualified professional
Important

For research use only. Not for human consumption. Apex Academy is an educational reference describing findings reported in published and preclinical literature. Nothing here is medical advice, a protocol, or a recommendation to administer any compound to humans or animals. Many compounds described are investigational and are not approved by the FDA or other regulators for the prevention, treatment, or cure of any condition. Their long-term safety and pharmacokinetics remain incompletely characterized. Dose ranges, where shown, describe quantities used in cited research models - not instructions for use. Consult a qualified, licensed professional before making any health decision.