Tesamorelin
A growth-hormone-releasing peptide - and the one here with a genuine FDA-approved track record.
The approved GHRH.
Tesamorelin is a GHRH analog with something most peptides here lack: a full FDA approval, for reducing excess visceral fat in HIV-associated lipodystrophy. That gives it a real human-trial backbone.
At a glance
Where the research focuses.
Visceral fat
Its approved use - reducing deep abdominal fat, shown in controlled trials.
Liver fat / NAFLD
Studied for reducing liver fat, with promising trial signals.
Cognition (ageing)
Examined for cognitive effects in older adults via GH/IGF-1.
GH / IGF-1 support
Raises the body's own GH in a relatively physiological way.
GHRH with a record.
Tesamorelin raises the body's own GH through the GHRH receptor, and its visceral-fat effect is backed by randomised controlled trials - unusual depth for this category.
Its approval is specific, but the underlying human data make it one of the better-evidenced GH-axis compounds.
Strength of the evidence.
- FDA approval for HIV lipodystrophy
- Visceral-fat reduction in RCTs
- GHRH-receptor mechanism established
- Liver-fat reduction signals
- Cognitive research in ageing
- General anti-ageing positioning
- Long-term off-label use
How it works
GHRH receptor
Stimulates pituitary GH release physiologically.
EstablishedVisceral fat
Preferentially mobilises deep abdominal fat.
RCT-backedIGF-1 axis
Raises IGF-1 within a controlled range.
ClinicalTolerability
Generally well tolerated; injection-site and joint effects reported.
DocumentedHow it moves through the system
Reconstitution calculator
How much diluent to mix into the vial, and the concentration that results. The suggested volume reaches a clean working stock; the calculator does the arithmetic from figures you enter. These describe solution preparation for research handling — not instructions for use in humans or animals.
Signs of a quality compound
Tesamorelin is FDA-approved (Egrifta) for a specific indication; other uses are off-label or research. It is prohibited in competitive sport. Among the GH-axis compounds here, it has the strongest human evidence base.
- For research purposes only
- Not for human consumption
- Not FDA approved
- Consult a qualified professional










